When you are looking for work it is important to never give up. You have to "hit the pavement", often very hard, to get the job you have been dreaming about. With the unemployment rate at just under 8% this past November 2010 - the competition out there is stiff. You can expect a lot of companies to not even look at your resume, but don't let that discourage you- think of it as an opportunity.
"An opportunity?", you might be wondering to yourself. If you think about it the jobs that are just tossing you aside without looking at all you have to offer is not going to be a place you want to work. It is the jobs that take weeks screening potential employees that are the good ones. Those people care and it will show when you are employed. So don't give up hope and keep sending your applications out there - a good rule of thumb is no less than 5 a day.